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Failed to initialize the CLR?

I'm getting the following messages trying to run comparisons on some (though not all) servers. Additionally, all have "clr enabled" = 0 in sp_config.

X Registering data sources
servername.databasename-Reading assemblies

Failed to initialize the Common Language Runtime (CLR) v2.0.50727 with HRESULT 0x80131522. You need to restart SQL Server to use CLR integration features.

This was on a 2008R2 SP2 server; other 2008 SP2 servers, also with clr disabled, don'[t have this problem.

Is there a way to get this to work? It's exceedingly frustrating.
mbourgon
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