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It's a windows synchronisation object that should have been freed when the service was stopped. You can download Process Explorerfrom the Sysinternals site, and perform a search for Global\SQBMutex_CHARLOTTE. That should tell you which application is still holding a reference to that object. Depending on which application is it, you could choose to delete the reference.
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The following error appears in the EventLog: SQL Backup Agent startup error: error initialising IPC objects. Error creating mutex (already exists): Global\SQBMutex_CHARLOTTE
Is the only remedy a restart of the server to remove the DLL from memory?